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Cover Frontiers of Cord Blood Science

Frontiers of Cord Blood Science

Erschienen 2009 bei Springer-Verlag; Springer, London
Sprache: English
400 Seiten
ISBN 978-1-84800-167-1

Inhaltsverzeichnis

1;Foreword;5
2;Preface;7
3;Acknowledgments;10
4;Contents;11
5;Contributors;13
6;Introduction;16
6.1;References;26
7;Umbilical Cord Blood Stem Cell ( Basic Science);27
7.1;Placental and Pregnancy Stem Cells;28
7.1.1;Hematopoietic Stem Cells;28
7.1.2;Mesenchymal Stem Cells;28
7.1.3;Endothelial Progenitor Cells;30
7.1.4;Plasticity;30
7.1.5;Embryology of the Placenta/Amnion, Amniotic Fluid, and the Umbilical Cord;30
7.1.6;The Ontogeny of Stem Cells;33
7.1.7;Hematopoietic Stem Cells;34
7.1.8;Mesenchymal Stem Cells;35
7.1.9;Endothelial Progenitor Cells;36
7.1.10;Fetal Cells in Maternal Circulation;38
7.1.11;References;40
7.2;Cord Blood Stem Cells - The Basic Science;44
7.2.1;Transplantation Biology;45
7.2.2;Transplantation Immunology;45
7.2.3;Cord Blood Stem Cell Amplification;46
7.2.4;Cord Blood Stem Cells and Regenerative Medicine;47
7.2.5;References;48
7.3;Stem Cells from Umbilical Cord Blood;51
7.3.1;Introduction;52
7.3.2;Hematopoietic Stem Cells;52
7.3.3;Endothelial Progenitor Cells;74
7.3.4;Mesenchymal Stem Cells;82
7.3.5;Other Stem Cells;96
7.3.6;Final Remarks;99
7.3.7;List of Abbreviations;100
7.3.8;References;101
7.4;Ex Vivo Expansion of Cord Blood;115
7.4.1;Cellular Content of CB;115
7.4.2;Ex Vivo Expanded Cells Provide Rapid Engraftment;116
7.4.3;Selection of CB Products for Ex Vivo Expansion;116
7.4.4;Availability of Clinical Grade Reagents;117
7.4.5;Clinical ExperienceWith Ex Vivo Expanded Cells;118
7.4.6;Ex Vivo Expansion of CB-MNC on MSC;118
7.4.7;Summary;119
7.4.8;Disclosure Statement;120
7.4.9;References;120
7.5;Mesenchymal Stem Cells: Applications in Cell and Gene Therapy;121
7.5.1;Introduction;121
7.5.2;Isolation and Culture of Mesenchymal Stem Cells;122
7.5.3;Phenotypic Characterization of Mesenchymal Stem Cells;126
7.5.4;Differentiation Potential of MSCs;127
7.5.5;Therapeutic Applications of MSCs;129
7.5.6;References;137
7.6;Non-hematopoietic Stem and Progenitor Cells Derived From Human Umbilical Cord Blood;147
7.6.1;Introduction;147
7.6.2;Mesenchymal Stromal Cells;149
7.6.3;Endothelial Progenitor Cells;159
7.6.4;Embryonic Stem Cell-like Cells Derived from CB;164
7.6.5;Conclusion;166
7.6.6;References;166
8;Umbilical Cord Blood Stem Cell Transplantation;182
8.1;Cord Blood Transplantation for Pediatric Non- Malignant Conditions;183
8.1.1;Introduction and Description of the Evolution of the Field;183
8.1.2;ReasonsWhy One Should Use Cord Blood in These Diseases;184
8.1.3;Potential Disadvantages of Using Cord Blood;188
8.1.4;Current Issues for Specific Diseases;189
8.1.5;How Do We Balance the Place of Cord Blood Against Other Sources of Stem Cells?;207
8.1.6;How Can We Improve?;207
8.1.7;Summary;208
8.1.8;References;209
8.2;Cord Blood Transplantation for Hematologic Malignancies;217
8.2.1;Cord Blood Transplantation in Children with Acute Leukemia;217
8.2.2;Cord Blood Transplantation in Adults;222
8.2.3;New Strategies in Cord Blood Transplantation;225
8.2.4;Conclusion;228
8.2.5;References;229
8.3;Double Umbilical Cord Blood Transplantation in Adults;231
8.3.1;Pre-Clinical Background;231
8.3.2;Cord Blood Unit Availability;232
8.3.3;Clinical Studies in Cord Blood Transplantation;233
8.3.4;Studies in Children - Unrelated Cord Blood Transplants;233
8.3.5;Studies in Adults - Single Cord Blood Transplants - Ablative Regimens;234
8.3.6;Adult Cord Blood Transplantation - Single Cord Blood - Reduced Intensity Regimen;236
8.3.7;Adult Cord Blood Transplantation - Double Cord Blood Transplantation - Myeloablative Regimen;237
8.3.8;Adult Double Cord Blood Transplantation - Reduced Intensity Regimen;238
8.3.9;Adult Cord Blood Transplantation - Chimerism Analysis;240
8.3.10;Combination Cord Blood and Bone Marrow Transplants;240
8.3.11;New Applications of Cord Blood Transplantation;241
8.3.12;Conclusion;242
8.3.13;References;242
9;Transfusion of Cord Blood;246
9.1;Placental Umbilical CordWhole Blood Transfusion: A True Blood Substitute to Combat

Kurztext / Annotation

Cord blood is a significant source of hematopoietic stem and progenitor cells for the treatment of blood and genetic disorders. Cord blood is also an alternative to embryos as a source of tissue for regenerative medicine. Cells from cord blood have been shown to transdifferentiate into nonhematopoietic cells, including those of the brain, heart, liver, pancreas, bone, and cartilage, in tissue culture and in animal systems. Recently it has been demonstrated that both cardiac and glial cell differentiation of cord blood donor cells occurred in recipients of unrelated donor cord blood transplantation as part of a treatment regime for Krabbe disease and Sanfilippo syndrome. These observations raise the possibility that cord blood may serve as a source of cells to facilitate tissue repair and regeneration in the future. CD34 stem cell-rich umbilical cord whole blood transfusion has the potential to have an immediate benefit of better tissue oxygenation with an additional delayed benefit of possible engraftment of umbilical cord stem cells.

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